منابع مشابه
Designing Safer Chemicals
Many of the > 83,000 chemicals currently used in commerce pose potential toxic hazards to human health and the environment. Numerous policies and systems are in place to try to identify harmful chemicals that are already in use, but removing these problem chemicals once they are already in the marketplace can be difficult, time-consuming, and costly. In an ideal world, chemists would be able to...
متن کاملDesigning safer chemicals: predicting the rates of metabolism of halogenated alkanes.
A computational model is presented that can be used as a tool in the design of safer chemicals. This model predicts the rate of hydrogen-atom abstraction by cytochrome P450 enzymes. Excellent correlations between biotransformation rates and the calculated activation energies (delta Hact) of the cytochrome P450-mediated hydrogen-atom abstractions were obtained for the in vitro biotransformation ...
متن کاملDesigning Safer and Greener Antibiotics.
Since the production of the first pharmaceutically active molecules at the beginning of the 1900s, drug molecules and their metabolites have been observed in the environment in significant concentrations. In this review, the persistence of antibiotics in the environment and their associated effects on ecosystems, bacterial resistance and health effects will be examined. Solutions to these probl...
متن کاملDesigning safer health care through responsive regulation.
Self-regulation by the health professions, while improving, is no longer enough; external drivers for safer health care include governments, funders and consumers. Enforced self-regulation is often more promising than a "command and control" strategy. Research evidence on the responsive regulatory pyramid and its options offers lessons for health care policy makers and managers. Start at the ba...
متن کاملA New Approach for Designing Safer Collision Avoidance Systems
The Traffic Alert and Collision Avoidance System (TCAS) has been shown to significantly reduce the risk of mid-air collision and is currently mandated worldwide on all large transport aircraft. Engineering the collision avoidance logic was a very costly undertaking that spanned several decades. The development followed an iterative process where the logic was specified using pseudocode, evaluat...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2013
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.1206349